Safety First and Foremost!
… and it is not good science if it is not conducted safely!


Brückner Group-Specific Standard Operation Procedures (CB-LSOPs)

A printed copy of the signed CB-LSOPs is in R415 in the resource shelf.

Specific Chemicals and Compound Classes:
CB-LSOP-HNO3  CB-LSOP-BF3_Et2O CB-LSOP-Methylating_Agents
CB-LSOP-Metal Hydrides CB-LSOP-Liquid N2 CB-LSOP-KOH-iPrOH_Base_Bath
CB-LSOP-Thiophosgene CB-LSOP-Hydrazines CB-LSOP-Hydrogenation_Catalysts
CB-LSOP-Ozone CB-LSOP-Halogenated_Solvents CB-LSOP-H2S
CB-LSOP-Br2 CB-LSOP-Flammable_Solvents CB-LSOP-Cr(IV)reagents
CB-LSOP-Diazomethane + al_techbull_al180 CB-LSOP-OsO4 CB-LSOP-Organolithiums
Procedures and Instruments:
CB-LSOP-Vacuum_Manifold CB-LSOP-THF_&_CH2Cl2_still CB-LSOP-Flame drying

Other Resources

emergency pullUConn’s EH&S Chemical Health and Safety Website

Safety Resources Provided by EH&S

EH&S Safety Checklist (v.1.0)

Identifying and Evaluating Hazards in Research Laboratories (ACS 2015) (19.3 MB pdf)

ACS Academic Safety Culture Report 2012  (ACS 2012) (1.2 MB)

Chemical Structure and Accidental Explosion Risk (Churchill, D. G. Chem. Educ. 200683, 1798–1803.)

Graphic Examples of What Not To Do:

oil bath
This oil bath was run overnight at a much too high temperature! Soot was everywhere on the ceiling of the fume hood. Check the temp limits of the type of oil you are using. A saturated paraffin oil is only good to about 200 °C; for temperatures up to 300 °C, a silicone oil should be used. Care must be taken with hot oil baths not to generate smoke or you risk the oil to burst into flames…

sodium in still
This is a dollop of liquid sodium on the bottom of a dried-out THF still! No running of this still overnight (or if you are out of the lab for extended periods of time)! No running it without heat set above the set point indicated. No running it without the automated power cut-off when the cooling fails!

Image from a mishap in the NMR lab at University of Illinois, Urbana–Champaign. Do not bring ferrous materials near the 5 Gauss line (indicated on the floor) of the spectrometers! Cards with magnetic strips (credit and ATM cards) cellular phones, laptops and mechanical watches should also remain outside the 5 Gauss perimeter.